Catalog No.: PC-26996Not For Human Use, Lab Use Only.
TNG917 is a potent, selective, histone substrate-competitive, orally active dual inhibitor of EHMT1/2, shows high selectivity over other methyltransferases.
TNG917 is a potent, selective, histone substrate-competitive, orally active dual inhibitor of EHMT1/2, shows high selectivity over other methyltransferases.
TNG917 relieved H3K9-mediated repression, restored interferon-stimulated gene expression, and triggered secretion of T-cell chemoattractant cytokines, including CXCL10, in cancer cells.
TNG917 monotherapy led to marked tumor growth inhibition, while combination with anti-PD1 therapy produced complete, durable regressions and established protective immune memory in both syngeneic and humanized mouse models.
