TNG917 | EHMT1/2 inhibitor | Probechem Biochemicals

Chemical Structure : TNG917

TNG917 (TNG-917)

Catalog No.: PC-26996Not For Human Use, Lab Use Only.

TNG917 is a potent, selective, histone substrate-competitive, orally active dual inhibitor of EHMT1/2, shows high selectivity over other methyltransferases.

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Biological Activity

TNG917 is a potent, selective, histone substrate-competitive, orally active dual inhibitor of EHMT1/2, shows high selectivity over other methyltransferases.
TNG917 relieved H3K9-mediated repression, restored interferon-stimulated gene expression, and triggered secretion of T-cell chemoattractant cytokines, including CXCL10, in cancer cells.
TNG917 monotherapy led to marked tumor growth inhibition, while combination with anti-PD1 therapy produced complete, durable regressions and established protective immune memory in both syngeneic and humanized mouse models.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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TNG917 (TNG-917)

Biological Activity

Physicochemical Properties

References

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