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Chemical Structure : TOP5300
Catalog No.: PC-20750Not For Human Use, Lab Use Only.
TOP5300 (TOP05300) is a potent, selective, orally active allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 9.72 nM, 80-fold selectivity over hLHR.
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TOP5300 (TOP05300) is a potent, selective, orally active allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 9.72 nM, 80-fold selectivity over hLHR.
TOP5300 stimulated concentration-dependent increases in estradiol production in the absence or presence of a low concentration of rec-hFSH (0.2 pM) in cultured rat granulosa cells.
TOP5300 also stimulated concentration-dependent increases in testosterone production from cultured rat Leydig cells.
TOP5300 is a full agonist on the FSH receptor in human granulosa cells, stimulates estradiol production with EC50 of 474 nM.
TOP5300 (5, 10 and 25 mg/kg, p.o.) stimulated follicular maturation in immature rats.
| M.Wt | 570.47 | |
| Formula | C28H29Cl2N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Selva Nataraja, et al. Front Pharmacol. 2021 Jan 14;11:602593.
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