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Chemical Structure : TP-064
CAS No.: 2080306-20-1
Catalog No.: PC-63546Not For Human Use, Lab Use Only.
TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM, shows high selectivity (>100-fold) for PRMT4 over other PRMTs.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM.
TP-064 shows high selectivity (>100-fold) for PRMT4 over other PRMTs.
TP-064 reduces dimethylation of BAF155 (IC50=340±30 nM) and MED12 (IC50=43±10 nM) in a dose-dependent manner in cell-baed assays.
TP-064 inhibits the proliferation of a subset of multiple myeloma cell lines (NCI-H929, RPMI8226, Cell IC50 of 379 and 886 nM, respectively) with affected cells arrested in G1 phase of the cell cycle, but has no effect on acute myeloid leukemia, colon cancer, or lung cancer cell lines.
| M.Wt | 458.606 | |
| Formula | C28H34N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
250 mM in DMSO (114.65 mg/mL) |
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| Chemical Name/SMILES |
N-methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide |
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1. Nakayama K, et al. Oncotarget. 2018 Apr 6;9(26):18480-18493.
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