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Chemical Structure : TP-3654
CAS No.: 1361951-15-6
Catalog No.: PC-42322Not For Human Use, Lab Use Only.
TP-3654 is a potent, selective, orally active second-generation PIM inhibitor with Ki of 5, 42 and 239 nM for Pim1, 2 and 3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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TP-3654 is a potent, selective, orally active second-generation PIM inhibitor with Ki of 5, 42 and 239 nM for Pim1, 2 and 3, respectively.
TP-3654 exhibits submicromolar activity in UM-UC-3 bladder cancer cell line.
TP-3654 displays favorabl hERG and CYP450 inhibition profiles compared with SGI-1776, reduces tumor growth in vivo xenografts.
| M.Wt | 418.4553096 | |
| Formula | C22H25F3N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM |
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| Chemical Name/SMILES |
Cyclohexanemethanol, α,α-dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-, trans- |
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1. Foulks JM, et al. Neoplasia. 2014 May;16(5):403-12.
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