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TPCA-1

Chemical Structure : TPCA-1

CAS No.: 507475-17-4

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TPCA-1 (IKK-2 Inhibitor IV)

Catalog No.: PC-42243Not For Human Use, Lab Use Only.

TPCA-1 (IKK-2 Inhibitor IV) is a potent, selective and orally bioavailable IKK-2 inhibitor with IC50 of 63 nM, TNF cell IC50 of 0.4 uM.

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5 mg $58 In stock
10 mg $88 In stock
25 mg $148 In stock
50 mg $248 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TPCA-1 (IKK-2 Inhibitor IV) is a potent, selective and orally bioavailable IKK-2 inhibitor with IC50 of 63 nM, TNF cell IC50 of 0.4 uM.
TPCA-1 displays >100-fold selectivity over IKK-1.

Physicochemical Properties

M.Wt 279.2901
Formula C12H10FN3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-

References

1. Baxter A, et al. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22.

2. Park BK, et al. Nat Med. 2007 Jan;13(1):62-9.

3. Amaya M, et al. PLoS One. 2014 Feb 19;9(2):e86745.

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