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Chemical Structure : TPPU
CAS No.: 1222780-33-7
Catalog No.: PC-42350Not For Human Use, Lab Use Only.
TPPU is a potent soluble epoxide hydrolase (sHE) inhibitor with IC50 of 37 nM and 3.7 nM for monkey and human sHE, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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TPPU is a potent soluble epoxide hydrolase (sHE) inhibitor with IC50 of 37 nM and 3.7 nM for monkey and human sHE, respectively.
TPPU attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice.
TPPU significantly decreases not only the percentages but also the proliferative capacity of different populations of cardiac fibroblasts.
TPPU also reduces the migration of fibroblasts into the heart from the bone marrow in vivo.
| M.Wt | 359.3435096 | |
| Formula | C16H20F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- |
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1. Sirish P, et al. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5618-23.
2. Ulu A, et al. Br J Pharmacol. 2012 Mar;165(5):1401-12.
3. Ren Q, et al. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1944-52.
4. Goswami SK, et al. oxicol Appl Pharmacol. 2015 Dec 15;289(3):419-27.
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