Chemical Structure : TREM2 agonist S9
CAS No.:
TREM2 agonist S9
Catalog No.: PC-26079Not For Human Use, Lab Use Only.
TREM2 agonist S9 is a potent, small molecule Triggering receptor expressed on myeloid cells-2 (TREM2) agonist with MST binding KD of 0.95 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TREM2 agonist S9 is a potent, small molecule Triggering receptor expressed on myeloid cells-2 (TREM2) agonist with MST binding KD of 0.95 uM.
TREM2 agonist S9 increases SYK phosphorylation in HEK cells expressing TREM2/DAP12, but no in parental HEK cells lacking TREM2/DAP12 expression.
TREM2 agonist S9 engages TREM2 in a manner that preserves signal propagation rather than inducing biased or abortive activation.
TREM2 agonist S9 (1, 5, and 10 µM) modulates Aβ-induced microglial responses in a TREM2-dependent manner in human iPSC-derived microglia, exhibits reduction in IL-1β secretion.
TREM2 agonist S9 preserves synaptic markers in neuron–microglia co-cultures under amyloid stress, exhibits strong suppression of Aβ-induced inflammatory signaling, TREM2-dependent activity, modulation of ApoE secretion, and preservation of synaptic markers.
Physicochemical Properties
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M.Wt
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390.44
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Formula
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C23H22N2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(benzofuran-3-yl)-4-methoxy-N-methyl-5-(3-methylenecyclobutane-1- carboxamido)benzamide
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References
1. Nada H, et al. bioRxiv [Preprint]. 2026 Jan 21:2026.01.19.700278.
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