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Chemical Structure : TRIF agonist AV-C
Catalog No.: PC-63179Not For Human Use, Lab Use Only.
TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM).
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TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM); activates IFNAR-mediated transcription and translation of antiviral effector genes, AV-C-mediated, IRF3-dependent innate activation occurs independently of adaptor proteins IPS-1/MAVS and STING but requires TRIF.
| M.Wt | 421.446 | |
| Formula | C22H16FN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pryke KM, et al. MBio. 2017 May 2;8(3). pii: e00452-17.
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