Catalog No.: PC-27674Not For Human Use, Lab Use Only.
TS-002266 is a potent and selective RNA terminal uridylyl transferase enzymes 4 and 7 (TUT4/7) inhibitor, blocks miRNA uridylation in vitro with biochemical IC50 of 69 and 16 nM for TUT4 and TUT7, respectively.
TS-002266 is a potent and selective RNA terminal uridylyl transferase enzymes 4 and 7 (TUT4/7) inhibitor, blocks miRNA uridylation in vitro with biochemical IC50 of 69 and 16 nM for TUT4 and TUT7, respectively.
TS-002266 substantially reduces uridylation and demonstrate in vitro and in vivo antiproliferative activity specifically in FOCAD-deleted cancer.
TS-002266 significantly decreases the proliferation and colony formation of human NOMO-1 cells.
TS-002266 sensitizes AML cells to venetoclax in a variety of blood cancers.
TS-002266 reduces their proliferation and induces apoptosis in murine Meis1/Hoxa9 transformed cells.
TS-002266 exhibits reduced colony formation capacity in primary AML patient samples.
