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Chemical Structure : TTA03-107
Catalog No.: PC-20197Not For Human Use, Lab Use Only.
TTA03-107 is a potent, selective HDAC1 inhibitor with Ki of 3.22 and 17.6 nM for HDAC1/2, respectively.
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TTA03-107 is a potent, selective HDAC1 inhibitor with Ki of 3.22 and 17.6 nM for HDAC1/2, respectively.
TTA03-107 (5 mg/kg/d, drinking water) exhibited antiarthritic efficacy in CIA-induced DBA/1J mice, alleviated the severity of arthritis.
TTA03-107 reduced the severity of autoimmune arthritis without obvious adverse effects in CIA and CAIA models.
TTA03-107 suppressed the production of inflammatory cytokines, such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-17A, in serum and joint tissue.
TTA03-107 dampened the M1 differentiation and inflammatory cytokine production in vitro treatment of BMDMs.
TTA03-107 also suppressed the differentiation of Th17 cells.
| M.Wt | 433.49 | |
| Formula | C22H19N5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wei Zhe, et al. Biol Pharm Bull. 2022;45(9):1364-1372.
2. Patent WO2019235501A1.
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