TTBK1 inhibitor 62

Chemical Structure : TTBK1 inhibitor 62

Catalog No.: PC-27632Not For Human Use, Lab Use Only.

TTBK1 inhibitor 62 is a potent, selective, brain-penetrant ATP-competitive Tau tubulin kinase 1 (TTBK1) inhibitor with IC50 of 0.89 uM, >100-fold selective over TTBK2.

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Biological Activity

TTBK1 inhibitor 62 is a potent, selective, brain-penetrant ATP-competitive Tau tubulin kinase 1 (TTBK1) inhibitor with IC50 of 0.89 uM, >100-fold selective over TTBK2.
TTBK1 inhibitor 62 significantly decreases TDP-43 phosphorylation at Ser409/410 in in SH-SY5Y cells.
TTBK1 inhibitor 62 significantly restores nuclear TDP-43 localization.
TTBK1 inhibitor 62 does not elicit ciliogenesis-related toxicity.
TTBK1 inhibitor 62 restored cognitive deficits, conferred neuroprotection in the frontal cortex, and reduced microglial activation in FTD CaMKIIα-TDP-43 mouse model.

Physicochemical Properties

M.Wt	276.30
Formula	C16H12N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(Furan-2-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

References

1. Sanchez-Santos C, et al. J Med Chem. 2026 Aug 13;69(15):19451-19481.