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Chemical Structure : TTQC-1
Catalog No.: PC-47105Not For Human Use, Lab Use Only.
TTQC-1 is a potent activator of the large-conductance Ca2+-activated K+ channel (BKCa channel), directly and reversibly activates the macroscopic current of BKCa channels expressed in Xenopus oocytes from both sides of the cellular membrane, increases the maximum conductance and shifted the half activation voltage to the left with EC50 of 2.8 uM.
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TTQC-1 is a potent activator of the large-conductance Ca2+-activated K+ channel (BKCa channel), directly and reversibly activates the macroscopic current of BKCa channels expressed in Xenopus oocytes from both sides of the cellular membrane, increases the maximum conductance and shifted the half activation voltage to the left with EC50 of 2.8 uM.
TTQC-1 delayed the kinetics of channel deactivation without affecting channel activation.
In the isolated smooth muscle cells of rat urinary bladder, TTQC-1 increased the K+ currents which can be blocked by iberiotoxin.
Oral administration of TTQC-1 to hypertensive rats decreased the urination frequency.
| M.Wt | 446.337 | |
| Formula | C18H12BrN3O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Heeji Jo, et al. Eur J Pharmacol. 2022 Jul 15;927:175055.
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