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Chemical Structure : TX2-121-1
Catalog No.: PC-35752Not For Human Use, Lab Use Only.
TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor.
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TX2-121-1 is a bivalent hydrophobically tagged adamantane derivative of TX1-85-1, a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor.
TX2-121-1 induces degradation and interferences with Her2/Her3 and c-Met/Her3 interactions, prevents Her3 heterodimerization.
TX2-121-1 induces preferential death of Her3-dependent cell lines with an EC50 in the range of 0.8-1.4 uM.
| M.Wt | 716.931 | |
| Formula | C42H52N8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xie T, et al. Nat Chem Biol. 2014 Dec;10(12):1006-12.
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