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TZ9

Chemical Structure : TZ9

CAS No.: 1002789-86-7

TZ9 (TZ-9;Rad6-SMI-9)

Catalog No.: PC-45500Not For Human Use, Lab Use Only.

RAD6 SMI#9 (TZ9, RAD6 inhibitor 9) is a specific small molecule inhibitor of ubiquitin-conjugating enzyme (E2) Rad6, inhibits Rad6B-ubiquitin thioester formation and subsequent ubiquitin transfer to histone H2A.

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Biological Activity

RAD6 SMI#9 (TZ9, RAD6 inhibitor 9) is a specific small molecule inhibitor of ubiquitin-conjugating enzyme (E2) Rad6, inhibits Rad6B-ubiquitin thioester formation and subsequent ubiquitin transfer to histone H2A.
RAD6 SMI#9 inhibited MDA-MB-231 cell proliferation with IC50 of 6 uM.
Rad6 SMI#9 (10 uM) induces MDA-MB-231 G2–M-arrest and decreases β-catenin protein levels, downregulates β-catenin.
Gold nanoparticle (GNP)-based SMI#9 inhibited the TNBC growth in BRCA1 wild-type and BRCA1-mutant TNBC xenograft models.

Physicochemical Properties

M.Wt 366.3309
Formula C17H14N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 40 mg/mL

Chemical Name/SMILES

1,3,5-Triazine-2-methanol, 4-amino-6-(phenylamino)-, 2-(4-nitrobenzoate)

References

1. Sanders MA, et al. J Biol Chem. 2017 Jun 23;292(25):10347-10363.

2. Sanders MA, et al. Mol Cancer Ther. 2013 Apr;12(4):373-83.

3. Haynes B, et al. Nanomedicine. 2016 Apr;12(3):745-757.

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