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Chemical Structure : TZB-30878
Catalog No.: PC-47113Not For Human Use, Lab Use Only.
TZB-30878 is a potent, selective, orally bioavailable 5-HT1A agonist and 5-HT3 antagonist, selectively binds to human 5-HT1A and 5-HT) receptors with Kd values of 0.68 and 8.90 nM, respectively.
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TZB-30878 is a potent, selective, orally bioavailable 5-HT1A agonist and 5-HT3 antagonist, selectively binds to human 5-HT1A and 5-HT) receptors with Kd values of 0.68 and 8.90 nM, respectively.
Systemic administration of TZB-30878 inhibited 5-HT-induced bradycardia in a dose-dependent manner in rats, TZB-30878 produced signs of 5-HT syndrome in rats in behavioral assays.
TZB-30878 (1-10 mg/kg p.o.) normalized stress-induced defecation in a dose-dependent manner in IBS-like model in rats.
| M.Wt | 432.572 | |
| Formula | C25H32N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tamaoki S, et al. J Pharmacol Exp Ther. 2007 Sep;322(3):1315-23.
2. Asagarasu A, et al. J Med Chem. 2010 Nov 11;53(21):7549-63.
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