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Chemical Structure : Tacrolimus
CAS No.: 104987-11-3
Catalog No.: PC-22184Not For Human Use, Lab Use Only.
Tacrolimus (FK506) is a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex, inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription, shows immunosuppressive properties.
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|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 50 mg | $128 | In stock | |
| 100 mg | $198 | In stock | |
| 250 mg | $288 | In stock | |
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Tacrolimus (FK506) is a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex, inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription, shows immunosuppressive properties.
| M.Wt | 804.03 | |
| Formula | C44H69NO12 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone |
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1. Tocci MJ, et al. J Immunol. 1989 Jul 15;143(2):718-26.
2. Standaert RF, et al. Nature. 1990 Aug 16;346(6285):671-4.
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