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Chemical Structure : Tax-1-hDLG1 inhibitor 3
Catalog No.: PC-20988Not For Human Use, Lab Use Only.
Tax-1-hDLG1 inhibitor 3 is a small molecule inhibitor of Tax-1-hDLG1 interaction with EC50 of 11.5 uM, blocks HTLV-1 cell to cell transmission and viral replication.
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Tax-1-hDLG1 inhibitor 3 is a small molecule inhibitor of Tax-1-hDLG1 interaction with EC50 of 11.5 uM, blocks HTLV-1 cell to cell transmission and viral replication.
Tax-1-hDLG1 inhibitor 3 is a competitive inhibitor of the Tax-1-hDLG1 PDZ interaction, binds to both hDLG1 PDZ1 and PDZ2 domains, with affinity constants (KD) in the 14-21 uM.
Tax-1-hDLG1 inhibitor 3 (50 uM, 48 h) inhibits HTLV-1 viral replication in MT2 and C91 cells, decreases the expression of the structural protein Gag for both cell lines, does not show anti-viral effect against HIV-1.
| M.Wt | 430.39 | |
| Formula | C25H15FO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Maseko SB, et al. Antiviral Res. 2023 Jul 20:105675.
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