1,2,3,6-Tetragalloylglucose (TeGG) | UGT1A1 inhibitor

Chemical Structure : TeGG

CAS No.: 79886-50-3

TeGG (1,2,3,6-Tetragalloylglucose)

Catalog No.: PC-26075Not For Human Use, Lab Use Only.

1,2,3,6-Tetragalloylglucose (TeGG) is a substrate competitive inhibitor of UDP-glucuronyltransferase UGT1A1, inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 uM and 4.31 uM, respectively.

Packing	Price	Stock
5 mg	$258	In stock
10 mg	$398	In stock
25 mg	$598	In stock
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Biological Activity

1,2,3,6-Tetragalloylglucose (TeGG) is a substrate competitive inhibitor of UDP-glucuronyltransferase UGT1A1, inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 uM and 4.31 uM, respectively.
1,2,3,6-Tetragalloylglucose (TeGG) directly binds to UGT1A1 with Ki of 3.55 uM.
1,2,3,6-Tetragalloylglucose (TeGG) induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells.
1,2,3,6-Tetragalloylglucose (TeGG) also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease.
1,2,3,6-Tetragalloylglucose (TeGG) also inhibits heterogeneous nuclear ribonucleoprotein A2B1 (A2B1), inhibits hnRNPA2B1/TRAIL Axis to attenuate apoptosis and barrier dysfunction in intestinal epithelial cells.

Physicochemical Properties

M.Wt	788.58
Formula	C34H28O22
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4S,5R,6R)-5-Hydroxy-6-(((3,4,5-trihydroxybenzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4-triyl tris(3,4,5-trihydroxybenzoate)

References

1. Park JB, et al. Food Chem Toxicol. 2018 Oct;120:651-661.

2. Wang C, et al. Cell Signal. 2026 Feb 4;142:112411.

3. Zhang J, et al. Pharm Res. 2009 Sep;26(9):2066-80.

TeGG (1,2,3,6-Tetragalloylglucose)

Biological Activity

Physicochemical Properties

References

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