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Chemical Structure : Telaprevir
CAS No.: 402957-28-2
Catalog No.: PC-42476Not For Human Use, Lab Use Only.
A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $290.4 | In stock | |
| 100 mg | $528 | In stock |
Bulk size, bulk discount!
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A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM; demonstrates excellent antiviral activity both in genotype 1b HCV replicon cells (IC50=354 nM) and in human fetal hepatocytes (IC50=280 nM); shows excellent viral inhibition in vivo with favorable pharmacokinetic profile.
HCV Infection
Approved
| M.Wt | 679.8493 | |
| Formula | C36H53N7O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclopenta[c]pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydro-, (1S,3aR,6aS)- |
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1. Perni RB, et al. Antimicrob Agents Chemother. 2006 Mar;50(3):899-909.
2. Lin C, et al. J Biol Chem. 2004 Apr 23;279(17):17508-14.
3. Lin C, et al. J Biol Chem. 2005 Nov 4;280(44):36784-91.
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