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Chemical Structure : Temsavir
CAS No.: 701213-36-7
Catalog No.: PC-38563Not For Human Use, Lab Use Only.
Temsavir (BMS-626529) is a highly potent, small molecule HIV-1 attachment inhibitor with IC50 values of 2.26 nM, 0.34 nM and 1.3 nM for HIV-1 subtype A, B, and C envelope, repectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $168 | In stock | |
| 10 mg | $268 | In stock | |
| 25 mg | $458 | In stock | |
| 100 mg | Get quote |
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Temsavir (BMS-626529) is a highly potent, small molecule HIV-1 attachment inhibitor with IC50 values of 2.26 nM, 0.34 nM and 1.3 nM for HIV-1 subtype A, B, and C envelope, repectively.
Temsavir (BMS-626529) binds to non-ligand bound HIV-1 gp120 to inhibit HIV-1 interaction with host CD4+ T cells and subsequent HIV-1 binding and cell entry.
Temsavir (BMS-626529) inhibits infectivity of laboratory strains and clinical isolates of HIV-1 with EC50s of 0.4-2,000 nM, with no significant cytotoxic effect.
Temsavir (BMS-626529) is the active form of Fostemsavir.
| M.Wt | 473.5 | |
| Formula | C24H23N7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-benzoylpiperazin-1-yl)-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione |
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1. Meanwell NA, et al. J Med Chem. 2018 Jan 11;61(1):62-80.
2. Wang T, et al. J Med Chem. 2018 Jul 26;61(14):6308-6327.
3. Lai YT, et al. Nat Commun. 2019 Jan 3;10(1):47.
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