Tenalisib (RP6530) | p110δ/γ inhibitor

Chemical Structure : Tenalisib

CAS No.: 1639417-53-0

Tenalisib (RP-6530, RP6530)

Catalog No.: PC-60567Not For Human Use, Lab Use Only.

Tenalisib (RP6530) is a potent, selective, orally active p110δ/γ PI3K dual inhibitor with IC50 of 24.5 and 33.2 nM, respectively.

Packing	Price	Stock
5 mg	$58	In stock
10 mg	$88	In stock
25 mg	$128	In stock
50 mg	$218	In stock
100 mg	$358	In stock
250 mg		Get quote

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Biological Activity

Tenalisib (RP6530) is a potent, selective, orally active p110δ/γ PI3K dual inhibitor with IC50 of 24.5 and 33.2 nM, respectively.
Tenalisib (RP6530) displays good selectivity over p110α (>300-fold) and p110β (>100-fold) isoforms.
Tenalisib (RP6530) inhibits LPS induced CD19+ cell proliferation in human whole blood with EC50 of 250 nM, and LPS induced CD45R+ cell proliferation in mouse whole blood with EC50 of 101 nM.
Tenalisib (RP6530) shows the potential for treatment of cancer and inflammation diseases.

Physicochemical Properties

M.Wt	415.43
Formula	C23H18FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(1-((7H-purin-6-yl)amino)propyl)-3-(3-fluorophenyl)-4H-chromen-4-one

References

1. Vakkalanka S, et al. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2704.
2. Carmelo C, et al. Blood 2015 126:1495.

Tenalisib (RP-6530, RP6530)

Biological Activity

Physicochemical Properties

References

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