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Chemical Structure : Tenovin-D3
Catalog No.: PC-70105Not For Human Use, Lab Use Only.
A novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM.
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A novel selective, small-molecule inhibitor of sirtuin SITR2 with IC50 of 21.8 uM; shows much weaker actvity for SIRT1 (IC50>90 uM), SIRT3 and HDAC8; promotes expression of the cell-cycle regulator and p53 target p21(WAF1/CIP1) (CDKN1A) in a p53-independent manner, fails to increase p53 levels or transcription factor activity.
| M.Wt | 533.893 | |
| Formula | C22H27Cl3N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McCarthy AR, et al. Mol Cancer Ther. 2013 Apr;12(4):352-60.
2. Liu R, et al. Sci Rep. 2015 Feb 12;5:8415.
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