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Chemical Structure : Tetrodotoxin
CAS No.: 4368-28-9
Catalog No.: PC-43094Not For Human Use, Lab Use Only.
Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.
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|---|---|---|---|
| 1 mg | $188 | In stock | |
| 5 mg | $688 | In stock | |
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Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.
Tetrodotoxin-sensitive sodium channel (Nav) family include Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7, the Nav1.5, Nav1.8, and Nav1.9 channels are TTX-resistant.
Tetrodotoxin (TTx) inhibits the firing of action potentials in neurons by binding to the voltage-gated sodium channels in nerve cell membranes and blocking the passage of sodium ions into the neuron.
| M.Wt | 319.268 | |
| Formula | C11H17N3O8 | |
| Appearance | Solid | |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, 2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-, (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)- |
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1. Rogers M, et al. Assay Drug Dev Technol. 2016 Mar;14(2):109-30.
2. Frelin C, et al. J Biol Chem. 1983 Jun 25;258(12):7256-9.
3. Reiser G, et al. Brain Res. 1983 Feb 21;261(2):335-40.
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