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Chemical Structure : Them1 inhibitor U1
Catalog No.: PC-21866Not For Human Use, Lab Use Only.
Them1 inhibitor U1 is a selective, allosteric small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively bind the Them1 START domain with Kd of 5.97 uM.
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Them1 inhibitor U1 is a selective, allosteric small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively bind the Them1 START domain with Kd of 5.97 uM.
Them1 inhibitor U1 (10 uM) increases fatty acid oxidation rates in cultured primary brown adipocytes.
Them1 inhibitor U1 reverses Them1-mediated suppression of oxygen consumption rates and increases in glucose production in cell culture.
| M.Wt | 383.51 | |
| Formula | C21H25N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Krumm CS, et al. Mol Metab. 2023 Dec;78:101832.
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