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Chemical Structure : Thiamet G
CAS No.: 1009816-48-1
Catalog No.: PC-43111Not For Human Use, Lab Use Only.
Thiamet-G is a potent, selective O-GlcNAcase inhibitor with Ki of 21 nM for human O-GlcNAcase, blocks phosphorylation of tau both in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $548 | In stock |
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Thiamet-G is a potent, selective O-GlcNAcase inhibitor with Ki of 21 nM for human O-GlcNAcase, blocks phosphorylation of tau both in vitro and in vivo; decreases phosphorylation of tau in PC-12 cells at pathologically relevant sites including Thr231 and Ser396, also efficiently reduces phosphorylation of tau at Thr231, Ser396 and Ser422 in both rat cortex and hippocampus, which reveals the rapid and dynamic relationship between O-GlcNAc and phosphorylation of tau in vivo; stimulates chondrogenic differentiation both in vitro and in vivo.
| M.Wt | 248.2993 | |
| Formula | C9H16N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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| Chemical Name/SMILES |
5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)- |
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1. Yuzwa SA, et al. Nat Chem Biol. 2008 Aug;4(8):483-90.
2. Goldberg H, et al. Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E713-26.
3. Yuzwa SA, et al. Nat Chem Biol. 2012 Feb 26;8(4):393-9.
4. Andrés-Bergós J, et al. J Biol Chem. 2012 Sep 28;287(40):33615-28.
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