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Chemical Structure : Tilmacoxib
Catalog No.: PC-62672Not For Human Use, Lab Use Only.
Tilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM, dispalys no activity against COX-1 (IC50>100 uM).
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Tilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM, dispalys no activity against COX-1 (IC50>100 uM); significantly inhibits fibrosis, also inhibits growth of pulmonary metastases of colorectal cancer in rats.
Rheumatoid Arthritis
Phase 2 Discontinued
| M.Wt | 338.397 | |
| Formula | C16H19FN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wakitani K, et al. Jpn J Pharmacol. 1998 Nov;78(3):365-71.
2. Kobayashi H, et al. BMC Cancer. 2005 Mar 3;5:26.
3. Yamamoto H, et al. Gastroenterology. 2003 Aug;125(2):556-71.
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