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Tizanidine

Chemical Structure : Tizanidine

CAS No.: 51322-75-9

Tizanidine

Catalog No.: PC-27360Not For Human Use, Lab Use Only.

Tizanidine is a skeletal muscle relaxant and an orally effective central α2-adrenoceptor agonist (IC50=6 nM), exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons, also inhibits the proliferation, migration, and invasion of lung cancer cells.

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Biological Activity

Tizanidine is a skeletal muscle relaxant and an orally effective central α2-adrenoceptor agonist (IC50=6 nM), exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons, also inhibits the proliferation, migration, and invasion of lung cancer cells.

Physicochemical Properties

M.Wt 253.71
Formula C9H8ClN5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)benzo[c][1,2,5]thiadiazol-4-amine

References

1. Kamen L, et al. Curr Med Res Opin. 2008 Feb;24(2):425-39.

2. Granfors, M. T., et al. Br J Clin Pharmacol。 2004 Mar;57(3):349-53.

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