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Chemical Structure : Todalam
Catalog No.: PC-38550Not For Human Use, Lab Use Only.
Todalam is a novel small molecule tubulin inhibitor with IC50 of 8.8 uM against HeLa cells, fully inhibits microtubule formation with IC50 of 48 uM, acting as a reversible microtubule-destabilizing agent in vitro and in cells.
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Todalam is a novel small molecule tubulin inhibitor with IC50 of 8.8 uM against HeLa cells, fully inhibits microtubule formation with IC50 of 48 uM, acting as a reversible microtubule-destabilizing agent in vitro and in cells.
Todalam kills different type of mammalian cells, induces G2/M arrest, disrupts cellular microtubule networks, and can inhibit cell growth in a synergistic manner in combination with vinblastine.
Todalam achieves its effect by locking α-tubulin in an inactive conformational state and by sequestering tubulin dimers.
Todalam is the first-ever, fully rationally designed tubulin inhibitor with an original molecular mechanism of action.
| M.Wt | 377.385 | |
| Formula | C18H14F3N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tobias Mühlethaler, et al. Angew Chem Int Ed Engl. 2022 Apr 11;e202204052.
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