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Chemical Structure : Tolvaptan
CAS No.: 150683-30-0
Catalog No.: PC-45125Not For Human Use, Lab Use Only.
Tolvaptan (OPC-41061) is a highly potent selective, competitive vasopressin V2-receptor antagonist with Ki of 0.43 nM, >200-fold more selective than for V1A-receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Tolvaptan (OPC-41061) is a highly potent selective, competitive vasopressin V2-receptor antagonist with Ki of 0.43 nM, >200-fold more selective than for V1A-receptors.
Tolvaptan (OPC-41061) inhibits cAMP production induced by AVP with no intrinsic agonist activity.
Tolvaptan (OPC-41061) clearly produces dose-dependent aquaresis in rats.
Tolvaptan (OPC-41061) is orally active.
| M.Wt | 448.9413 | |
| Formula | C26H25ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl- |
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1. Yamamura Y, et al. J Pharmacol Exp Ther. 1998 Dec;287(3):860-7.
2. Kondo K, et al. Bioorg Med Chem. 1999 Aug;7(8):1743-54.
3. Miyazaki T, et al. Endocrinology. 2005 Jul;146(7):3037-43.
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