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Chemical Structure : Toreforant
Catalog No.: PC-63399Not For Human Use, Lab Use Only.
Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors.
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Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors; JNJ-38518168 acts as an antagonist in all species tested and inhibits histamine-induced eosinophil shape change in vitro; demonstrates anti-inflammatory activities in mouse models of asthma and arthritis.
Rheumatoid Arthritis
Phase 2 Clinical
| M.Wt | 392.551 | |
| Formula | C23H32N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thurmond RL, et al. J Rheumatol. 2016 Sep;43(9):1637-42.
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