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Chemical Structure : Triacsin C
Catalog No.: PC-22161Not For Human Use, Lab Use Only.
Triacsin C (WS 1228A) is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) with IC50 of 6.3 μM in Raji cells, inhibits TAG accumulation into lipid droplets (LD).
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Triacsin C (WS 1228A) is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) with IC50 of 6.3 μM in Raji cells, inhibits TAG accumulation into lipid droplets (LD).
Triacsin C has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters.
Triacsin C also act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.
Triacsin C inhibits pancreatic β-cell function by suppressing the mobilization of intracellular calcium.
| M.Wt | 207.28 | |
| Formula | C11H17N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kim Y, et al. Eur J Med Chem. 2012 Apr;50:311-8.
2. Dechandt CRP, et al. J Bioenerg Biomembr. 2017 Oct;49(5):399-411.
3. Matsuda D, et al. J Antibiot (Tokyo). 2008 May;61(5):318-21.
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