Chemical Structure : Triazole 1.1
CAS No.:
1526944-32-0
Triazole 1.1
Catalog No.: PC-24299Not For Human Use, Lab Use Only.
Triazole 1.1 is a potent, G protein signaling-biased κ opioid receptor (KOR) agonist with EC50 of 77.2 nM in [35S]GTPγS binding assays, with bias factor (G protein/βarrestin2) of 28.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Triazole 1.1 is a potent, G protein signaling-biased κ opioid receptor (KOR) agonist with EC50 of 77.2 nM in [35S]GTPγS binding assays, with bias factor (G protein/βarrestin2) of 28.
Triazole 1.1 induces KOR-mediated antinociception and suppresses chloroquine phosphate–induced scratching responses in C57BL/6 mice.
Triazole 1.1 does not decrease locomotor activity in mice.
Triazole 1.1 decreases dopamine concentrations in the nucleus accumbens in mice, but not U50,488H.
Triazole 1.1 promotes analgesia in the absence of dysphoria in the rat ICSS model.
Physicochemical Properties
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M.Wt
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430.45
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Formula
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C21H17F3N4OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(4-(furan-2-ylmethyl)-5-((4-methyl-3-(trifluoromethyl)benzyl)thio)-4H-1,2,4-triazol-3-yl)pyridine
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References
1. Brust TF, et al. Sci Signal. 2016 Nov 29;9(456):ra117.
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