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Chemical Structure : Trimetrexate
CAS No.: 52128-35-5
Catalog No.: PC-42556Not For Human Use, Lab Use Only.
A quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $320 | In stock | |
| 50 mg | $1120 | In stock |
Bulk size, bulk discount!
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A quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor; shows activity against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate.
Chemotherapeutic Agents
Discontinued
| M.Wt | 369.4176 | |
| Formula | C19H23N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]- |
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1. Weir EC, et al. Cancer Res. 1982 May;42(5):1696-702.
2. Diddens H, et al. Cancer Res. 1983 Nov;43(11):5286-92.
3. Elslager EF, et al. J Med Chem. 1983 Dec;26(12):1753-60.
4. Wong BK, et al. Drug Metab Dispos. 1990 Nov-Dec;18(6):980-6.
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