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Chemical Structure : TrkB agonist R13
Catalog No.: PC-20760Not For Human Use, Lab Use Only.
TrkB agonist R13 is a small molecular TrkB receptor agonist prodrug, inhibits asparagine endopeptidase (AEP) and promotes bone formation.
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TrkB agonist R13 is a small molecular TrkB receptor agonist prodrug, inhibits asparagine endopeptidase (AEP) and promotes bone formation.
R13 releases 7,8-DHF after absorption and significantly increases its oral bioavailability.
Oral administration of R13 elicits robust TrkB receptor activation in the brain and the gut and inhibits AEP via Akt-mediated T322 phosphorylation.
R13 not only represses AEP expression through blunting its upstream transcription factor C/EBPβ but also blocks AEP activation via BDNF/TrkB pathway-activated Akt.
R13 treatment significantly elevates OPG in both mice without altering RANKL, blocking trabecular bone loss in vivo.
| M.Wt | 368.35 | |
| Formula | C19H16N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jing Xiong, et al. Nat Commun. 2022 Aug 16;13(1):4820.
2. Chun Chen, et al. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):578-583.
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