Tubulin inhibitor 89

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Chemical Structure : Tubulin inhibitor 89

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Catalog No.: PC-25361Not For Human Use, Lab Use Only.

Tubulin inhibitor 89 is a novel potent colchicine-site inhibitor of tubulin, has significant cytostatic activity against human Hela (cervical) and HCT116 (colonic) tumor cells with IC50 of 1.13 and 0.65 uM respectively, interferes with the assembly of microtubules by inhibiting PI3K/Akt signaling pathway.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	350.47
Formula	C21H26N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-phenylpiperazin-1-yl)(2-(piperidin-1-yl)pyridin-3-yl)methanone

References

1. Shan P, et al. Cell Death Discov. 2025 Aug 19;11(1):392.

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