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Chemical Structure : U0126
CAS No.: 1173097-76-1
Catalog No.: PC-42845Not For Human Use, Lab Use Only.
U0126 (U0126-EtOH) is a potent, selective MEK (MAP2K) inhibitor with IC50 of 70 nM and 60 nM for MEK1 and MEK2, suppresses AP-1-mediated gene activation in transient transfection assays with IC50 of 0.96 uM.
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U0126 (U0126-EtOH) is a potent, selective MEK (MAP2K) inhibitor with IC50 of 70 nM and 60 nM for MEK1 and MEK2, suppresses AP-1-mediated gene activation in transient transfection assays with IC50 of 0.96 uM.
U0126 shows little to no effect on the kinase activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2, or Cdk4.
U0126 inhibits T cell proliferation in response to antigenic stimulation or cross-linked anti-CD3 plus anti-CD28 Abs, but has no effect on IL-2-induced proliferation.
U0126 reduces tumor size of tumor xenografts in nude mice.
| M.Wt | 426.5583 | |
| Formula | C20H22N6OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 49 mg/mL |
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| Chemical Name/SMILES |
Butanedinitrile, 2,3-bis[amino[(2-aminophenyl)thio]methylene]-, compd. with ethanol (1:1) |
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1. Favata MF, et al. J Biol Chem. 1998 Jul 17;273(29):18623-32.
2. DeSilva DR, et al. J Immunol. 1998 May 1;160(9):4175-81.
3. Bessard A, et al. Oncogene. 2008 Sep 11;27(40):5315-25.
4. Duncia JV, et al. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2839-44.
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