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U18666A

Chemical Structure : U18666A

CAS No.: 3039-71-2

U18666A (U 18666A)

Catalog No.: PC-49197Not For Human Use, Lab Use Only.

U18666A is a cationic sterol that blocks the movement of cholesterol out of lysosomes and also inhibits Ebola virus infections, targets niemann-Pick C1 (NPC1) which exports cholesterol derived from receptor-mediated uptake of LDL, and mediates cellular entry of Ebola virus.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

U18666A is a cationic sterol that blocks the movement of cholesterol out of lysosomes and also inhibits Ebola virus infections, inhibits the vesicular trafficking protein Niemann-Pick C1 (NPC1) which exports cholesterol derived from receptor-mediated uptake of LDL, and mediates cellular entry of Ebola virus.

Physicochemical Properties

M.Wt 424.066
Formula C25H42ClNO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3beta)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride

References

1. Bierkamper GG, et al. Brain Res. 1978 Jul 14;150(2):343-51.

2. Feiran Lu, et al. Elife. 2015 Dec 8;4:e12177.

3. Patel SC, et al. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1657-62.

4. Shoemaker CJ, et al. PLoS One. 2013;8(2):e56265.

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