Chemical Structure : UBE2D3 inhibitor QX-6
CAS No.:
2264085-55-2
UBE2D3 inhibitor QX-6
Catalog No.: PC-25849Not For Human Use, Lab Use Only.
UBE2D3 inhibitor QX-6 is a potent UBE2D3 (UbcH5c) inhibitor, binds to the catalytic active domain of UBE2D3 with MST KD of 12.68 nM, enhances IFN-γ-induced antigen peptide presentation in cancer cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UBE2D3 inhibitor QX-6 is a potent UBE2D3 (UbcH5c) inhibitor, binds to the catalytic active domain of UBE2D3 with MST KD of 12.68 nM, enhances IFN-γ-induced antigen peptide presentation in cancer cells.
QX-6 inhibited the E2-ubiquitin thioester conjugate activity of UBE2D3 in cell-free assays and inhibited TAP2 K63 linkage polyubiquitination in vitro.
QX-6 treatment enhanced and prolonged antigen presentation in IFN-γ-activated cancer cells, a response attenuated by UBE2D3.
QX-6 at doses of 10–100 mg/kg significantly inhibited tumor growth in immunocompetent subcutaneous KPC model, increased the population of tumor-infiltrating T lymphocytes in C57BL/6 mice.
QX-6 synergistically enhanced TCR-T-cell immunotherapy against PDAC, promoted the cytotoxicity of tumor-infiltrating CD8+ T cells in both CD45.2 donors and CD45.1 recipients.
Physicochemical Properties
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M.Wt
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458.40
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Formula
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C24H28BrNO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3S,3aS,9bR)-8-((2-bromobenzyl)oxy)-3-((dimethylamino)methyl)-6,9-dimethyl-3a,4,5,9b-tetrahydronaphtho[1,2-b]furan-2(3H)-one
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References
1. Wang S, et al. Nat Commun. 2025 Nov 28;16(1):10733.
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