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UC-764865

Chemical Structure : UC-764865

CAS No.: 2566480-63-3

UC-764865 (UC764865)

Catalog No.: PC-72869Not For Human Use, Lab Use Only.

UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.
UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.
Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.

Physicochemical Properties

M.Wt 324.398
Formula C18H16N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-1-(4-methoxyphenyl)-3-((6-methyl-1H-benzo[d]imidazol-2-yl)thio)prop-2-en-1-one

References

1. Laura Barreyro, et al. Sci Transl Med. 2022 Mar 9;14(635):eabb7695.

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