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Chemical Structure : UCI-LC0023
Catalog No.: PC-49216Not For Human Use, Lab Use Only.
UCI-LC0023 is a small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H.
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UCI-LC0023 is a small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H.
Treatment of TOV112D cells with UCI-LC0023 increased the detection with wild-type specific antibodies and decreased the p53R175H mutant specific signal.
UCI-LC0023 restores DNA binding of p53 mutants (R175H, Y220C, R248W, R282W, R273H, G245S) in vitro and in vivo and induces p53 target gene expression.
UCI-LC0023 is sufficient to correct the DNA binding defect of p53R175H.
UCI-LC0023 induces restoration of site-specific DNA binding of the p53R175H mutant to the promoters of the p53-dependent genes p21 and PUMA in TOV112D cells as demonstrated by ChIP.
| M.Wt | 293.282 | |
| Formula | C16H11N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Geetha Durairaj, et al. Cell Chem Biol. 2022 Aug 9;S2451-9456(22)00275-6.
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