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Chemical Structure : UK-396082
Catalog No.: PC-61820Not For Human Use, Lab Use Only.
UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI.
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UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10 nM; displays excellent selectivity over plasma carboxypeptidase N (>1,000-fold); exhibits antithrombotic efficacy in a rabbit model of venous thrombosis, yet has no effect on surgical bleeding in the rabbit; possesses excellent preclinical and clinical pharmacokinetic profile, and shows potential for the treatment of thrombosis and other fibrin-dependent diseases in humans.
Thrombosis
Phase 1 Discontinued
| M.Wt | 239.319 | |
| Formula | C12H21N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bunnage ME, et al. J Med Chem. 2007 Nov 29;50(24):6095-103.
2. Atkinson JM, et al. Matrix Biol. 2013 Jun 24;32(5):277-87.
3. Bridge K, et al. PLoS One. 2017 May 4;12(5):e0177117.
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