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Chemical Structure : UK-414495
Catalog No.: PC-70064Not For Human Use, Lab Use Only.
A potent and selective inhibitor of neutral endopeptidase (NEP) with IC50 of 18.9 nM for hNEP.
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A potent and selective inhibitor of neutral endopeptidase (NEP) with IC50 of 18.9 nM for hNEP; dose-dependently potentiates pelvic nerve-stimulated increases in VBF (EC50=37 nM); increases the amplitude and duration of VIP-induced increases in VBF in the anaesthetized rabbit.
| M.Wt | 339.453 | |
| Formula | C16H25N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pryde DC, et al. J Med Chem. 2006 Jul 13;49(14):4409-24.
2. Wayman CP, et al. Br J Pharmacol. 2010 May;160(1):51-9.
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