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Chemical Structure : UK5099
Catalog No.: PC-38841Not For Human Use, Lab Use Only.
UK 5099 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC), inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with IC50 of 50 nM.
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UK 5099 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC), inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with IC50 of 50 nM.
UK 5099 is a potent non-competitive inhibitor of pyruvate oxidation in castor-bean mitochondria.
UK 5099 impaired glucose tolerance in vivo.
| M.Wt | 288.3 | |
| Formula | C18H12N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Parvin R, et al. J Biol Chem. 1978 Mar 25;253(6):1944-6.
2. Brailsford MA, et al. Biochem J. 1986 Oct 15;239(2):355-61.
3. Patterson JN, et al. J Biol Chem. 2014 May 9;289(19):13335-46.
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