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Chemical Structure : UMK57
Catalog No.: PC-73363Not For Human Use, Lab Use Only.
UMK57 (UMK 57) is a small-molecule MACK (alias KIF2C) agonist that specifically potentiates the activity of the kinesin‐13 protein MCAK, suppresses chromosome mis-segregation in chromosomal instability (CIN) cancer cells.
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UMK57 (UMK 57) is a small-molecule MACK (alias KIF2C) agonist that specifically potentiates the activity of the kinesin‐13 protein MCAK, suppresses chromosome mis-segregation in chromosomal instability (CIN) cancer cells.
UMK57 targets MCAK in vivo but does not alter its levels or localization in cells.
UMK57 reduces lagging chromosome rates in human cancer cell lines by destabilizing kinetochore-microtubule (k-MT) attachments in metaphase.
UMK57 causes chromosome mis-segregation rebounds in UMK57-treated cancer cells.
UMK57 rescues age‐associated CIN and delays senescence.
UMK57 improves chromosome segregation fidelity in elderly cells, does not impact the mitotic fitness of younger cells.
| M.Wt | 295.404 | |
| Formula | C17H17N3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bernardo Orr, et al. Cell Rep. 2016 Nov 8;17(7):1755-1763.
2. Monika Barroso-Vilares, et al. EMBO Rep. 2020 May 6;21(5):e49248.
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