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Chemical Structure : UNC-3230
CAS No.: 1031602-63-7
Catalog No.: PC-61242Not For Human Use, Lab Use Only.
UNC-3230 (UNC3230) is a selective, small molecule inhibitor of PIP5K1C with IC50 of 41 nM, does not ihibits other lipid kinases including PI3Ks.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | $728 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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UNC-3230 (UNC3230) is a selective, small molecule inhibitor of PIP5K1C with IC50 of 41 nM, does not ihibits other lipid kinases including PI3Ks.
UNC-3230 shows selectivity (Kd<0.2 uM) for PIP5K1C and PIP4K2C.
UNC-3230 significantly reduces membrane PIP2 levels by ~45% in DRG neurons at 100 nM, also reduces LPA-evoked calcium signaling.
UNC-3230 demonstrates antinociceptive effects, reduces thermal and mechanical sensitization in models of chronic pain.
| M.Wt | ||
| Formula | ||
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5- (cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide |
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1. Wright BD, et al. Neuron. 2014 May 21;82(4):836-47.
2. Wright BD, et al. J Biomol Screen. 2015 Jun;20(5):655-62.
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