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Chemical Structure : UNC-CA2-103
Catalog No.: PC-22206Not For Human Use, Lab Use Only.
UNC-CA2-103 is a potent, selective tousled like kinase 2 (TLK2) inhibitor with enzyme IC50 of 18 nM, exhibit excellent selectivity over TLK1 (16% inhibition at 0.5 μM).
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UNC-CA2-103 is a potent, selective tousled like kinase 2 (TLK2) inhibitor with enzyme IC50 of 18 nM, exhibit excellent selectivity over TLK1 (16% inhibition at 0.5 μM).
UNC-CA2-103 also exhibits overall kinome selectivity (S(10) = 0.027) accross DiscoverX kinome panel (>400 kinases).
UNC-CA2-103 exhibits IC50 of 250 nM in ADP-Glo kinase activity assays.
UNC-CA2-103 is a useful kinase chemical tool for elucidation of TLK2 biology.
| M.Wt | 344.37 | |
| Formula | C20H16N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Christopher R M Asquith, et al. Eur J Med Chem. 2024 Apr 2:271:116357.
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