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Chemical Structure : UNC119-Src interaction inhibitor 3
Catalog No.: PC-36164Not For Human Use, Lab Use Only.
UNC119-Src interaction inhibitor 3 is a potent, specific small molecule inhibitor of UNC119-Src interaction with IC50 of 12 nM for displacement of the Src peptide from UNC119A.
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UNC119-Src interaction inhibitor 3 is a potent, specific small molecule inhibitor of UNC119-Src interaction with IC50 of 12 nM for displacement of the Src peptide from UNC119A.
UNC119-Src interaction inhibitor 3 selectivity released all N-myristoylated peptides from UNC119, but not the farnesyl-protein binding proteins PDE6d, AIPL1 and calmodulin.
UNC119-Src interaction inhibitor 3 binds to UNC119 in cells (Kd=71.8 nM), and induces redistribution of Src to endomembranes and reduction of activating Src autophosphorylation on Y419.
UNC119 inhibition in Src-dependent colorectal cancer cells results in the specific reduction of cell growth and clonogenic potential.
| M.Wt | 474.594 | |
| Formula | C22H26N4O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Garivet G, et al. Cell Chem Biol. 2019 Mar 13. pii: S2451-9456(19)30074-1.
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