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UNC4850

Chemical Structure : UNC4850

CAS No.:

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UNC4850 (UNC-4850)

Catalog No.: PC-38275Not For Human Use, Lab Use Only.

UNC4850 (UNC-4850) is a specific small-molecule inhibitor toward CDY Chromodomain CDYL1/2 with Kd of 0.47/0.42 uM, >10-fold selectivity over CDY1, CBX5 and CBX7.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UNC4850 (UNC-4850) is a specific small-molecule inhibitor toward CDY Chromodomain CDYL1/2 with Kd of 0.47/0.42 uM, >10-fold selectivity over CDY1, CBX5 and CBX7.
    NC4850 is a close analog of UNC3866, UNC4850 binds to the chromodomain of CDYL1/2 about 10-fold more potently than to that of CBX7 by ITC.

    Physicochemical Properties

    M.Wt 751.97
    Formula C40H61N7O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    O=C(N[C@@H](CO)C(N)=O)[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CC(C)C)=O)CC1=CC=CC=C1)=O)C)=O)CC2=CC=CC=C2)=O)CCCCN(CC)C(C)C

    References

    1. Cheng Dong, et al. Cell Chem Biol. 2020 Jul 16;27(7):827-838.e7.

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