Chemical Structure : UNI110
CAS No.:
2648334-60-3
UNI110
(UNI-110)
Catalog No.: PC-25314Not For Human Use, Lab Use Only.
UNI110 is a potent small molecule inhibitor of mismatch repair (MMR)-deficient cancer cells, selectively kills MutSa deficient cells with IC50 of 25.05 µM in HEC59 cells and 56.57 µM in HEC59-2 cells.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UNI110 is a potent small molecule inhibitor of mismatch repair (MMR)-deficient cancer cells, selectively kills MutSa deficient cells with IC50 of 25.05 µM in HEC59 cells and 56.57 µM in HEC59-2 cells.
UNI110 treatment significantly increases γH2AX levels specifically in MutSα-deficient cancer cells and in MSH2-knockdown cells.
UNI110 impairs HR through a mechanism independent of cell cycle regulation.
UNI110 disrupts homologous recombination (HR) repair by inhibiting the MSH2-MSH3 complex, likely through disruption of the MSH2-EXO1 interaction.
Physicochemical Properties
|
M.Wt
|
512.44
|
|
Formula
|
C27H19F3O7
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-oxo-2-phenyl-7-((4-(trifluoromethyl)benzyl)oxy)-4H-chromene-5,6-diyl diacetate
|
References
1. Amarsanaa E, et al. Anim Cells Syst (Seoul). 2025 Aug 4;29(1):502-511.
Contact Us
sales@probechem.com
