UP163 | VCP activator | Probechem Biochemicals

Chemical Structure : UP163

CAS No.: 591242-60-3

UP163 (UP-163)

Catalog No.: PC-27882Not For Human Use, Lab Use Only.

UP163 is a small molecule allosteric activator of VCP ATPase activity with EC50 of 9.0 uM and Emax of 204%, exhibits ATPase domain–specific effects, enhances clearance of intranuclear TDP-4FL inclusions in cells expressing GFP-TDP-4FL.

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Biological Activity

UP163 is a small molecule allosteric activator of p97/VCP ATPase activity with EC50 of 9.0 uM and Emax of 204%, exhibits ATPase domain–specific effects, enhances clearance of intranuclear TDP-4FL inclusions in cells expressing GFP-TDP-4FL.

Physicochemical Properties

M.Wt	430.86
Formula	C20H15ClN2O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-Chlorophenyl)(1,1-dioxidobenzo[d]isothiazol-3-yl)amino)ethyl furan-2-carboxylate

References

1. Phan JM, et al. J Clin Invest. 2024 May 23:e169039.

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UP163 (UP-163)

Biological Activity

Physicochemical Properties

References

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